[Review] Peroxisome proliferator-activated receptor g Its role in atherosclerosis and restenosis

Peroxisome proliferator-activated receptor g Its role in atherosclerosis and restenosis

Cardiovasc Radiat Med. 2004 Jan-Mar;5(1):44-8.

Rajbabu Pakala, Seung-Woon Rha, Pramod Kumar Kuchulakanti, Edouard Cheneau, Richard Baffour, Ron Waksman*

Cardiovascular Research Institute, Washington Hospital Center, 110 Irving Street, NW, Suite 4B-1, Washington, DC 20010, USA

Abstract Cellular proliferation and migration are fundamental processes that contribute to the injury response in major blood vessels. The resultant pathologies are atherosclerosis and restenosis. As we begin to understand the cellular changes associated with vascular injury, it is critical to determine whether the inhibition of growth and movement of cells in the vasculature could serve as a novel therapeutic strategy to prevent atherosclerosis and restenosis.

Keywords: Peroxisome proliferator-activated receptor g; Atherosclerosis; Restenosis