Abstract

Background: From several epidemiologic studies, it has been shown that there is a proportional correlation between the incidence of dysplipidemia and diabetes mellitus (DM). However, it is not clear that how much the dyslipidemia impact on development of new-onset DM, especially in Asian population.

Methods: We investigated the 4071 patients (pts) that was HbA1c level <6.0% and fasting glucose level < 100 mg/dL at baseline. The definition of hyperlipidemia was based on NECP guideline (hyperlipidemia group,765 and control group, 3306). The enrolled period was from January 2004 to September 2007 and follow-up period was to September 2012. To adjust potential confounders including age, gender, body mass index, hypertension, smoking history, chronic kidney disease, coronary artery disease, congestive heart failure, hyper/hypo-thyroidism, beta-blocker, diuretics, fasting glucose, and HbA1c, the statistics was performed using the logistic regression model. Also, Multivariable Cox-regression analysis by aforementioned variables was performed to determine the impact of statin therapy on the incidence of new-onset DM.

Results: Mean follow-up duration was 1722±904 days in all-pt group, 1738±940 days in hyperlipidemia group, and 1718±896 days in control group. The incidence of new onset DM was 9.3% in all-pt group, 13.2% in hyperlipidemia group, and 8.4% in control group (p-value<0.001). In cox-regression analysis adjusted for covariates, the incidence of new onset DM of hyperlipidemia group was higher than control group (hazard ratio; 1.39, figure).

View larger version:

• In this page
 
• In a new window

• Download as PowerPoint Slide

Figure 1. Cox-regression curve has shown that there was difference in the cumulative incidences of new-onset diabetes melllitus between hyperlipidemia and control groups.

Conclusions: In our study, the pts with hyperlipidemia had the 39% increased risk of new onset DM incidence during 5-year follow-up period in Asian population than those without hyperlipidemia