Core 2. Epidemiology and Prevention of CV Disease: Physiology, Pharmacology and LifestyleSession Title: Prevention Versus Promotion of Diabetes Mellitus Type 2: Updating Our Evolving Understanding |
Abstract 18170: Impact of Chronic Statin Therapy on Development of Glucose Intolerance and New-onset Diabetes Mellitus in Asian Population
Sang-Ho Park1; Seung Woon Rha2; Ung Jun1; Se-Whan Lee1; Won-Yong Shin1; Seung-Jin Lee1; Dong-Kyu Jin1; Byoung Geol Choi2; Se Yeon Choi2; Sung Il Im2; Sun Won Kim2; Jin Oh Na2; Seong Woo Han2; Cheol Ung Choi2; Hong Euy Lim2; Jin Won Kim2; Eung Ju Kim2; Chang Gyu Park2; Hong Seog Seo2; Dong Joo Oh21 Cardiology department, Soonchunhyang Univ Cheonan Hosp, Cheonan, Korea, Republic of
2 Cardiovascular Cntr, Korea Univ Guro Hosp, Seoul, Korea, Republic of
Background; There have been several reports that statin therapy is associated with a slightly higher incidence of new-onset diabetes mellitus (DM) or impaired glucose intolerance (IGT). It is still controversial whether the chronic statin therapy is a risk factor of IGT and new onset DM, especially in Asian population.
Methods; We investigated the 13,561 patients (pts) that was glycerate hemoglobin level < 6.0% and fasting glucose level < 124 mg/dL (statin therapy group=4016 and control group=9545). To adjust potential confounders including age, gender, hypertension, hyperlipidemia, chronic kidney disease, hyper/hypo-thyroidism, lipid profile, beta-blocker, diuretics, a propensity score matched analysis was performed using the logistic regression model. The primary end-point was the cumulative incidence of new-onset DM, IGT, and impaired fasting glucose (IFG). Also, Multivariable Cox-regression analysis by adjusted by aforementioned variables was performed to determine the impact of statin therapy on the incidence of new-onset DM, IGT, and IFG.
Results; Mean follow-up duration was 534±604 days in all-pt group, and 608±607 days in propensity score matching group. Baseline characteristics was similar between the two groups except hyperlipidemia (11.1% vs. 3.5%, p<0.001). In Kaplan-Meyer curve, there was no difference between the two groups (p=0.501, figure A). Also, in cox-regression analysis performed in all pts, statin therapy was not associated with the increased incidence of primary end-point (figure B).
Conclusions; In our study, there was no clear association with statin therapy and IGT and new-onset DM in a series of cardiovascular pts in Asian population.
Author Disclosures: S. Park: None. S. Rha: None. U. Jun: None. S. Lee: None.W. Shin: None. S. Lee: None. D. Jin: None. B. Choi: None. S. Choi: None. S. Im: None. S. Kim: None. J. Na: None. S. Han: None. C. Choi: None. H. Lim:None. J. Kim: None. E. Kim: None. C. Park: None. H. Seo: None. D. Oh: None.
Key Words: Statins • Disease management
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