TCT-341 Impact of Chronic Statin Therapy on Development of Glucose Intolerance and New-onset Diabetes Mellitus in Asian Population

• Sang-Ho Park¹, 
• Seung-Woon Rha², 
• Ung Jun¹, 
• Se-Whan Lee¹, 
• Won-Yong Shin¹, 
• Seung Jin Lee¹, 
• Dong-Kyu Jin¹, 
• Byoung Geol Choi², 
• Se Yeon Choi², 
• Sung Il Im², 
• Sun Won Kim², 
• Jin Oh Na², 
• Seong Woo Han²,
• Cheol Ung Choi², 
• Hong Euy Lim², 
• Jin Won Kim², 
• Eung Ju Kim², 
• Chang Gyu Park², 
• Hong Seog Seo²,
• Dong Joo Oh²

• ¹ Cardiology Department, Soonchunhyang university cheonan hospital, Cheonan, Korea, Republic of
• ² Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea, Republic of

Background

There have been several reports that statin therapy is associated with a slightly higher incidence of new-onset diabetes mellitus(DM) or impaired glucose intolerance(IGT). It is still controversial whether the chronic statin therapy is a risk factor of IGT and new onset DM, in Asian population.

Methods

We investigated the 13,561 patients(pts) that was HbA1c level <6.0% and fasting glucose level <124 mg/dL(statin therapy group=4016 and control group=9545). To adjust potential confounders including age, gender, hypertension, hyperlipidemia, chronic kidney disease, hyper/hypo-thyroidism, lipid profile, beta-blocker, diuretics, a propensity score matched analysis was performed using the logistic regression model. The primary end-point was the cumulative incidence of new-onset DM, IGT, and impaired fasting glucose(IFG). Also, Multivariable Cox-regression analysis adjusted aforementioned variables was performed to determine the impact of statin therapy on the incidence of new-onset DM, IGT, and IFG.

Results

Mean follow-up duration was 534±604 days in all group, and 608±607 days in propensity score matching group. Baseline characteristics was similar between the two groups except hyperlipidemia (11.1% vs. 3.5%, p<0.001). In Kaplan-Meyer curve, there was no difference between the two groups (p=0.501, figure A). Also, in cox-regression analysis performed in all pts, statin therapy was not associated with the increased incidence of primary end-point(figure B).

Conclusions

In our study, there was no clear association with statin therapy and IGT and new-onset DM in a series of cardiovascular pts in Asian population.

Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.