IMPACT OF DIABETES ON ANGIOGRAPHIC AND CLINICAL OUTCOMES OF ACUTE MYOCARDIAL INFARCTION PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION EXCLUSIVELY TREATED WITH PITAVASTATIN [FROM THE LIVALO ACUTE MYOCARDIAL INFARCTION STUDY (LAMIS)]
- Cardiovascular Center, Korea University Guro Hospital, Seoul, South Korea, Livalo Acute Myocardial Infarction Study, Seoul, South Korea
Background
Statin therapy, a lipophilic statin Pitavastatin (Livalo) in acute myocardial infarction (AMI) setting may play an important role by not only reducing LDL-cholesterol, but also through the pleiotrophic effects, especially in diabetic patients (pts).
Method
This study consisted of 802 consecutive AMI pts underwent percutaneous coronary intervention (PCI) at 10 major centers in Korea. Pitavastatin 2mg/day was administered from the AMI presentation time. We investigated whether there are differences in 6 months angiographic and 12 months clinical outcomes between the diabetic and non-diabetic pts.
Results
A total 699 pts (87.1%) were finished 12-month clinical follow up. The baseline clinical characteristics were not similar between the two groups that diabetes group had more elderly, hypertension, previous PCI, multi-vessel disease, left main lesion and lower LV ejection fraction. At 6 months, angiographic outcomes were similar between the two groups. At 12 months, total death, repeat PCI, TVR-major adverse cardiac events (MACE), and total MACE were higher in the diabetes group in univariate analysis. However, after baseline adjustment by multivariate analysis, diabetes was an independent predictor of TVR-MACE (OR 2.042, 95% CI 1.063-3.924, p=0.032).
Conclusions
Despite of worse clinical and procedural characteristics in diabetes group, major clinical outcomes were similar with those of non-diabetes group except higher incidence of TVR-MACE in the diabetes group.
Copyright © 2012 Published by Elsevier Inc. All rights reserved.
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