Objectives

There have been little data regarding the association between composite of both left ventricular mass index (LVMI) and LV diastolic function and CACS. The objective of this study is to determine whether there are association between the composite of both LVMI and septal E/E′ ratio (E/E′) and coronary artery calcium score (CACS) severity in subjects with normal LV ejection fraction.

Methods

We investigated 1230 consecutive subjects that CACS, LVMI and E/E′ were measured by coronary computed tomography (CT) and echocardiography. LVMI and septal E/E′ ratio were compared between the CACS=0 group and CACS>0 group. Further, severity of CACS (no, mild, moderate, and severe calcification) were evaluated according to LVMI and septal E/E′ ratio. According to the composite of LVMI≥90 g/m2 and E/E′≥15, three groups were categorized as follows; ‘echo scoring system'=0,1,2.

Results

In multivariate regression analysis, both LVMI, and E/E′ were independent predictors of CACS>0. Each CACS of the 3 groups was 155.99±386.50, 287.51±745.52, and 489.00±913.49, respectively (p<0.001). In the post hoc analysis, there was statistically significant difference among the three groups. In the multivariate linear regression analysis, ‘echo scoring system' was an independent predictor of CACS.

Conclusions

In our study, LVMI and E/E′ were associated with presence and severity of CACS. The combination with LVMI and E/E' can be more accurate predictors of CASC than LVMI or E/E′ alone.

Copyright © 2014 Published by Elsevier Inc.