Background

Several studies have examined the association of biomarkers of iron metabolism with measures of peripheral arterial disease. Few studies, however, have evaluated the association between biomarkers of iron metabolism and mortality in critical limb ischemia (CLI).

Methods

Serum ferritin, iron (Fe), and total iron binding capacity (TIBC) were measured in 82 patients (pts) with CLI underwent endovascular therapy (EVT). The all enrolled pts had the below-the-knee (BTK) lesions and EVT was successfully performed. The patients with in-hospital mortality were excluded. The 66 of 82 patients assessed 1-year clinical follow-up (survivor group=57, non-survivor group=9).

Results

There were no significant differences in age, gender, hypertension, cerebrovascular accident, myocardial infarction, current smoking, dyslipidemia, chronic kidney disease between the survivor and non-survivor groups. As shown in the table, the survivor group had the higher serum ferritin level than non-survivor. However, there were no significant differences in Fe and TIBC in both groups. When ferritin was classified into high and low groups, the high ferritin group had more 1-year mortality than the low ferritin group (table).

Conclusions

In our study, increased serum ferritin level was associated with higher 1-year mortality in CLI pts who underwent successful EVT.

Copyright © 2014 Published by Elsevier Inc.