Background

Peripheral arterial disease (PAD) is an important predictor of adverse clinical outcomes following coronary revascularization. Patients with PAD have been found to have higher rates of adverse outcomes and poorer survival compared with patients without PAD. However, there have been limited data for long term clinical outcomes in patients with PAD undergoing percutaneous coronary intervention (PCI) in drug eluting stent (DES) era.

Method

The study population consisted of 2903 consecutive patients underwent PCI from April 2007 to November 2010. Two-year cumulative major clinical outcomes of patients with PAD (n=101) were compared with patients without PAD (n=2802).

Result

Baseline characteristics were balanced except patients with PAD were older (66.76 ± 10.1 vs. 62.90 ± 11.3 years, p = 0.020), had more diabetes (61.8 vs. 27.6 %, p = 0.002) and had longer total lesion length (50.38 ± 47.14 mm vs. 41.24 ± 39.93 mm, p = 0.005). Patients with PAD showed a strong trend toward higher rate of total mortality (13.6 vs. 6.3%, p = 0.051) despite of successful PCI results, but there was no significant difference in the incidence of cardiac death, target lesion revascularization (TLR), target vessel revascularization (TVR) and major adverse cardiac events (MACE, Table).

Conclusion

In our study, patients with PAD were associated with higher trend of increased total mortality up to 2 years as compared with those without PAD group following successful PCI, suggesting more special care should be exercised for this particular subset of patients.

Copyright © 2014 Published by Elsevier Inc.