Background

There is limited evidence regarding predictors associated with clinical outcomes of patients with chronic total occlusion (CTO) successfully treated with drug-eluting stents (DESs).

Methods

We investigated the 249 patients (pts) with de novo CTO lesions successfully treated with DESs from 2004 to 2010. All major adverse cardiovascular events (ALL-MACEs) were defined as composite of total death, any myocardial infarction (MI), target vessel revascularization (TVR) and non-target vessel revascularization. The association of ALL-MACEs with clinical, biochemical and procedural variables including age, male gender, hypertension, diabetes mellitus, smoking, hyperlipidemia, acute MI, multi-vessel disease, left main involvement, prior PCI, cilostazol, left ventricular ejection fraction <30 %, Hemoglobin level, Creatinine level, LDL-cholesterol<100 mg/dL, Glycated hemoglobin<7.0 %, High sensivity-CRP, number of total stents, IVUS-guided PCI, adjuvant ballooning was examined.

Results

The 12-month follow-up has been performed in the 242 of 249 pts (97.2%). The incidence of ALL-MACEs was the 40 of 242 patients (16.5%). Multivariate logistic regression was used to identify predictors affecting 1-year ALL-MACE. Left main involvement was significantly associated with 1-year ALL-MACEs and prior PCI history had a trend to be associated with 1-year ALL-MACEs (Table).

Conclusion

In our study, left main involvement was an important independent predictor associated with 1-year MACE following successful CTO intervention with DES.

Copyright © 2014 Published by Elsevier Inc.