Background

There are limited data comparing angiographic and clinical outcomes of re-stenotic stented chronic total occlusive (CTO) lesion successfully revascularized with drug-eluting stents (DESs) with those of de novo CTO lesion.

Methods

The study population consisted of consecutive 269 CTO patients (pts) who successfully treated with DESs between January 2004 and June 2010. A total 249 pts with de novo CTO lesion and 20 pts with re-stenotic stented CTO lesion were included for analysis. The 6-to-9 month angiographic and 2-year clinical outcomes were compared between the 2 groups.

Results

The baseline clinical characteristics were similar between the two groups except prior myocardial infarction, LDL-cholesterol level, number of total implanted stent and use of cilostazol. Angiographic outcomes at 6-to-9 months were similar between the two groups. At 2-year follow-up, the incidence of major clinical outcomes including all death, any myocardial infarction, any revascularization, target lesion and vessel revascularization (TLR and TVR) and major adverse cardiac events (MACEs) were similar between the two groups (Table). Further, even after adjustment of baseline differences with multivariate analysis adjusted by age, gender, dyslipidemia, LVEF, Lefevre classification, all the major clinical outcomes were similar between the two groups.

Conclusion

In our study, there were no difference in 6-to-9 month angiographic and 2-year clinical outcomes between pts with stented and de novo CTO lesions once the CTO pts were successfully treated with DESs.

Copyright © 2014 Published by Elsevier Inc.CRT-139.pdf